Original articles

Research center for Molecular Identification of Food Hazards

Toxicology in food

Absorption, tissue distribution, tissue metabolism and safety of a-mangostin in mangosteen extract using mouse models

Initiates file downloadAcetaldehyde targets superoxide dismutase 2 in liver cancer cells inducing transient enzyme impairment and a rapid transcriptional recovery

Initiates file downloadAdverse effects of high glucose levels on somite and limb development in avian embryos

Initiates file downloadAn aqueous extract of Limoniastrum guyonianum gall induces anti-tumor effects in melanoma-injected mice via modulation of the immune response

Initiates file downloadAntrodia salmonea in submerged culture exhibits antioxidant activities in vitro and protects human erythrocytes and low-density lipoproteins from oxidative modification

Initiates file downloadApoptosis in MCF-7 breast cancer cells induced by S- alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite

Initiates file downloadAssessment of micronuclei and sister chromatid exchange frequency in the petroleum industry workers in province of Vojvodina, Republic of Serbia

Initiates file downloadBaicalein inhibits lipid accumulation by regulating early adipogenesis and m-TOR signaling

Initiates file downloadBenzyl butyl phthalate exposure impairs learning and memory and attenuates neurotransmission and CREB phosphorylation in mice

Initiates file downloadBetulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt pathways in B16F10 cells

Initiates file downloadBiochemical and biological assessment of the inhibitory potency of extracts from vinification byproducts of Vitis vinifera extracts against glycogen phosphorylase

Initiates file downloadBlockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells

Initiates file downloadChronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats

Initiates file downloadCommercial squids: Characterization, assessment of potential health benefits/risks and discrimination based on mineral, lipid and vitamin E concentrations

Initiates file downloadCytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds

Initiates file downloadDietary levels of acrylamide affect rat cardiomyocyte properties

Initiates file downloadDietary L-methionine supplementation mitigates gamma-radiation induced global DNA hypomethylation: Enhanced metabolic flux towards S-adenosyl-L-methionine (SAM) biosynthesis increases genomic methylation potential

Initiates file downloadDifferential effect of manool – A diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells

Initiates file downloadDisturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments

Initiates file downloadDoxorubicin induced apoptosis was potentiated by neferine in human lung adenocarcima, A549 cells

Initiates file downloadEvaluation of global sequence comparison and one-to-one FASTA local alignment in regulatory allergenicity assessment of transgenic proteins in food crops

Initiates file downloadEvaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Initiates file downloadEvaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase

Initiates file downloadEvaluation of the mutagenicity and genotoxic potential of carvacrol and thymol using the Ames Salmonella test and alkaline, Endo IIIand FPG-modified comet assays with the human cell line Caco-2

Initiates file downloadEvaluation of toxicity of essential oils palmarosa, citronella, lemongrass and vetiver in human lymphocytes

Initiates file downloadExposure assessment of Malondialdehyde, 4-Hydroxy-2-(E)-Nonenal and 4-Hydroxy-2-(E)-Hexenal through specific foods available in Belgium

Initiates file downloadExposure to bis(maltolato)oxovanadium(IV) increases levels of hepcidin mRNA and impairs the homeostasis of iron but not that of manganese

Initiates file downloadFlaxseed oil during lactation changes milk and body composition in male and female suckling pups rats

Initiates file downloadFree radical scavenging and antioxidant activity of betanin: Electron spin resonance spectroscopy studies and studies in cultured cells

Initiates file downloadGalla rhois exerts its antiplatelet effect by suppressing ERK1/2 and PLCb phosphorylation

Initiates file downloadHepatoprotective effect of polyphenols rich methanolic extract of Amorphophallus commutatus var. wayanadensis against CCl4  induced hepatic injury in swiss albino mice

Initiates file downloadHepatotoxicity and genotoxicity of patulin in mice, and its modulation by green tea polyphenols administration

Initiates file downloadHigh concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species

Initiates file downloadHigh mutagenic activity of juice from pak choi (Brassica rapa ssp. chinensis) sprouts due to its content of 1-methoxy-3-indolylmethyl glucosinolate, and its enhancement by elicitation with methyl jasmonate

Initiates file downloadHuman health risk assessment and dietary intake of organochlorine pesticides through air, soil and food crops (wheat and rice) along two tributaries of river Chenab, Pakistan

Initiates file downloadHypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats

Initiates file downloadIlimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK–CHOP signaling pathways

Initiates file downloadImpairment of cell cycle progression by sterigmatocystin in human pulmonary cells in vitro

Initiates file downloadInfluence of lipoic acid on testicular toxicity induced by bi-n-butyl phthalate in rats

Initiates file downloadInhibitory effect of galangin on atopic dermatitis-like skin lesions

Initiates file downloadInterleukin-17 mediates triptolide-induced liver injury in mice

Initiates file downloadIn vivo effects of deoxynivalenol (DON) on innate immune responses of carp (Cyprinus carpio L.)

Initiates file downloadIron oxide nanoparticles mediated cytotoxicity via PI3K/AKT pathway: Role of quercetin

Initiates file downloadMetabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp

Initiates file downloadMetallothioneins attenuate paraquat-induced acute lung injury in mice through the mechanisms of anti-oxidation and anti-apoptosis

Initiates file downloadModulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells

Initiates file downloadMultiple pathways are involved in palmitic acid-induced toxicity

Initiates file downloadMutagenicity and genotoxicity studies of arruva, an R,R-monatin salt isomer

Initiates file downloadNeuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia

Initiates file downloadNew insights into the mechanism of neurolathyrism: L-b-ODAP triggers [Ca2+]i accumulation and cell death in primary motor neurons through transient  receptor potential channels and metabotropic glutamate receptors

Initiates file downloadNitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells

Initiates file downloadPerfluorooctane sulfonate blocked autophagy flux and induced lysosome membrane permeabilization in HepG2 cells

Initiates file downloadPGE2 production is suppressed by chemically-synthesized D7-eicosatrienoic acid in macrophages through the competitive inhibition of COX-2

Initiates file downloadPomegranate juice consumption increases GSH levels and reduces lipid and protein oxidation in human blood

Initiates file downloadPre-clinical in vitro and in vivo safety evaluation of bovine whey derived osteopontin, Lacprodan_ OPN-10

Initiates file downloadProbabilistic assessment of exposure to nail cosmetics in French consumers

Initiates file downloadProtective effect of curcumin against heavy metals-induced liver damage

Initiates file downloadProtective effect of dietary flaxseed oil on arsenic-induced nephrotoxicity and oxidative damage in rat kidney

Initiates file downloadProtective effect of polydatin, a natural precursor of resveratrol, against cisplatin-induced toxicity in rats

Initiates file downloadProtective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death

Initiates file downloadPurification, characterization and immunoreactivity of b0-component, a major allergen from the roe of large yellow croaker (Pseudosciaena crocea)

Initiates file downloadQuercetin attenuates chronic ethanol hepatotoxicity: Implication of ‘‘free’’ iron uptake and release

Initiates file downloadReproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid

Initiates file downloadRiboflavin (vitamin B-2) reduces hepatocellular injury following liver ischaemia and reperfusion in mice

Initiates file downloadRisk assessment, formation, and mitigation of dietary acrylamide: Current status and future prospects

Initiates file downloadRole of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes

Initiates file downloadRole of Nrf2 activation and NF-jB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice

Initiates file downloadRole of oxidative stress in Deoxynivalenol induced toxicity

Initiates file downloadSafety assessment of the butyrate-producing Butyricicoccus pullicaecorum strain 25-3T, a potential probiotic for patients with inflammatory bowel disease, based on oral toxicity tests and whole genome sequencing

Initiates file downloadSafety assessment of the fermented Phylloporia ribis (Lonicera japonica Thunb.) mycelia by oral acute toxicity study in mice and 90-day feeding study in rats

Initiates file downloadSafety evaluation of zeaxanthin concentrate (OmniXan™): Acute, subchronic toxicity and mutagenicity studies

Initiates file downloadSalidroside induces neuronal differentiation of mouse mesenchymal stem cells through Notch and BMP signaling pathways

Initiates file downloadSix months chronic toxicological evaluation of naringin in Sprague–Dawley rats

Initiates file downloadSoy isoflavones administered to rats from weaning until sexual maturity affect ovarian follicle development by inducing apoptosis

Initiates file downloadStandardized ethyl acetate fraction from the roots of Brassica rapa attenuates the experimental arthritis by down regulating inflammatory responses and inhibiting NF-jB activation

Initiates file downloadStudy of the migration phenomena of specific metals in canned tomato paste before and after opening. Validation of a new quality indicator for opened cans

Initiates file downloadSubchronic toxicity evaluation of c-aminobutyric acid (GABA) in rats

Initiates file downloadSystemic toxicity induced by paclitaxel in vivo is associated with the solvent cremophor EL through oxidative stress-driven mechanisms

Initiates file downloadTDS exposure project: Relevance of the Total Diet Study approach for different groups of substances

Initiates file downloadThe effect of kiwifruit (Actinidia deliciosa) cysteine protease actinidin on the occludin tight junction network in T84 intestinal epithelial cells

Initiates file downloadThe effects of bioactive compounds from plant foods on mitochondrial function: A focus on apoptotic mechanisms

Initiates file downloadThe fate of deoxynivalenol and ochratoxin A during the breadmaking process, effects of sourdough use and bran content

Initiates file downloadThe flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function

Initiates file downloadThe interaction of plant-growth regulators with serum albumin: Molecular modeling and spectroscopic methods

Initiates file downloadToll-like receptor 4-mediated ROS signaling pathway involved in Ganoderma atrum polysaccharide-induced tumor necrosis factor-a secretion during macrophage activation

Initiates file downloadTOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFjB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells

Initiates file downloadTopical application of Gallic acid suppresses the 7,12-DMBA/Croton oil induced two-step skin carcinogenesis by modulating anti-oxidants and MMP-2/MMP-9 in Swiss albino mice

Initiates file downloadTotal contents of arsenic and associated health risks in edible mushrooms, mushroom supplements and growth substrates from Galicia (NW Spain)

Initiates file downloadToxic effects of silver nanoparticles and nanowires on erythrocyte rheology

Initiates file downloadToxicologic evaluation of Dichrostachys glomerata extract: Subchronic study in rats and genotoxicity tests

Initiates file downloadTranslating reference doses into allergen management practice: Challenges for stakeholders

Initiates file downloadUrinary excretion of arsenicals following daily intake of various seafoods during a two weeks intervention

Initiates file downloadUrsolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of b-catenin degradation

Initiates file downloadVicenin 2 isolated from Artemisia capillaris exhibited potent anti-glycation properties

Initiates file downloadWithaferin A is an inhibitor of endothelial protein C receptor shedding in vitro and in vivo

Initiates file downloadAn immunomagnetic-bead-based enzyme-linked immunosorbent assay for sensitive quantification of fumonisin B1

Initiates file downloadDegradation of fumonisin B1 by cinnamon essential oil

Initiates file downloadDevelopment of acetylcholinesterase biosensor based on platinum carbon aerogels composite for determination of organophosphorus pesticides

Initiates file downloadEvaluation of pesticide residues in honey from different geographic regions of Colombia

Initiates file downloadUse of boron-doped diamond electrode pre-treated cathodically for the determination of trace metals in honey by differential pulse voltammetry